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Neurogenic disorders
  Peripheral

  • Diabetes mellitus
  • Autonomic neuropathy
  • Hirschsprung disease
  • Chagas disease
  • Intestinal pseudoobstruction

  Central

  • Multiple sclerosis
  • Spinal cord injury
  • Parkinson disease
  • Irritable bowel syndrome

     

Non-neurogenic disorders

  • Hypothyroidism
  • Hypokalemia, Hypercalcemia 
  • Anorexia nervosa
  • Pregnancy
  • Panhypopituitarism
  • Systemic sclerosis
  • Myotonic dystrophy
     

 

Table 2_ Differential Diagnosis Of Constipation.png


Drugs
  Analgesics

  Anticholinergics

  • Antihistamines
  • Antispasmodics
  • Antidepressants
  • Antipsychotics

  Cation-containing agents

  • Iron supplements
  • Aluminum (antacids, sucralfate)
  • Barium

  Neurally active agents

  • Opiates
  • Antihypertensives
  • Ganglionic blockers
  • Vinca alkaloids
  • Calcium channel blockers
  • 5HT3 antagonists
     

Idiopathic constipation

  • Normal colonic transit
  • Slow transit constipation
  • Dyssynergic defecation
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